This three disc set includes the remaining five episodes of Season 5 and first seven episodes of Season 6, excluding " Blue Harvest".

JB Hi-Fi has also released a limited special edition in Australia and New Zealand, which includes the DVD and a T-shirt, labeled as a "Collector's Edition". Special features include commentaries on every episode, deleted scenes, and featurettes including footage from Comic-Con 2008. It is notable that the final episode, When You Wish Upon a Weinstein, is the final episode of Season 3, but it originally aired after Season 3, as it was previously banned. Special features include audio commentaries, deleted scenes, animatics from " Seahorse Seashell Party", " Back to the Pilot", and " Family Guy Viewer Mail No.This three-disc set includes all twenty three episodes of Season 10 (" Lottery Fever" – " Internal Affairs").

Special features include 6 audio commentary tracks, deleted scene animatics, seven minutes of the unaired pilot pitch, and two featurettes.Also, this is the first Family Guy DVD to receive an 18 certificate in Ireland, but this is due to the content in the bonus features, not the episodes. Special features include commentaries on select episodes, originally televised episodes, deleted scenes, a featurette on " Road to the Multiverse" and Family Guy karaoke versions of some favorite Family Guy musical numbers.