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Bosch M, Fuentes MC, Audivert S, Bonachera MA, Peiro S, Cune J. Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. J Sci Food Agric 2014;94:803-9. [ PubMed abstract] For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation (WGO) advises restricting probiotic use to the strains and indications that have proven efficacy [ 3]. Probiotic Selection and Use Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] Sairenji T, Collins KL Evans DV. An update on inflammatory bowel disease. Prim Care 2017; 44: 673-92. [ PubMed abstract]
Probiotics for Kids - ProVen Probiotics | Life Concentrated Probiotics for Kids - ProVen Probiotics | Life Concentrated
A Cochrane Review of 63 RCTs in a total of 8,014 participants (primarily infants and children) found that single- and multi-strain probiotics significantly shortened the duration of acute infectious diarrhea by about 25 hours. These supplements also decreased the risk that the diarrhea would last 4 or more days by 59% and led to approximately one less bowel movement on the second day in patients who received probiotics compared with patients who did not [ 19]. The potential health benefits of probiotics are the focus of a great deal of scientific research. This section focuses on research on the use of probiotics to prevent or treat seven health conditions: atopic dermatitis, pediatric acute infectious diarrhea, antibiotic-associated diarrhea (AAD), inflammatory bowel disease, irritable bowel syndrome, hypercholesterolemia, and obesity. Atopic dermatitis Overall, the available evidence suggests that starting probiotic treatment with LGG or Saccharomyces boulardii within 2 days of the first antibiotic dose helps reduce the risk of AAD in children and adults age 18 to 64, but not in elderly adults. There is no evidence to suggest that the benefits are greater when more than one probiotic strain is used. Inflammatory bowel diseaseHigh levels of cholesterol in the blood or cholesterol trapped in arterial walls are risk factors for cardiovascular disease (CVD). Low-density lipoprotein (LDL) carries cholesterol to tissues and arteries. The higher the LDL level, the greater the risk is for CVD. High-density lipoprotein (HDL) carries cholesterol from the tissues to the liver and leads to its excretion. A low level of HDL increases a person’s risk of CVD. Our gut bacteria (microbiome) is fundamental to our health. It has a wide range of functions in our body and maintaining a balance of ‘good’ to ‘bad’ bacteria is key to supporting our microbiota. The International Scientific Association for Probiotics and Prebiotics defines probiotics as "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host" [ 1]. These microorganisms, which consist mainly of bacteria but also include yeasts, are naturally present in fermented foods, may be added to other food products, and are available as dietary supplements. However, not all foods and dietary supplements labeled as probiotics on the market have proven health benefits. Researchers have studied the use of probiotics to improve lipid profiles. The mechanisms of their effects on cholesterol concentrations include catabolism of cholesterol by increasing: Keeping our children healthy is a primary focus for parents and here at ProVen, we understand how difficult it can be to get our kids to eat a healthy diet each day.
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The probiotic strains used in the ProVen products are our own unique blends, known as Lab4, Lab4B and Lab4P. Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014;59:132-52. [ PubMed abstract] Silverman MA, Konnikova L, Gerber JS. Impact of antibiotics on necrotizing enterocolitis and antibiotic-associated diarrhea. Gastroenterol Clin North Am 2017;46:61-76. [ PubMed abstract] Kailasapathy K, Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Cell Biol 2000;78:80-8. [ PubMed abstract]Suzumura EA, Bersch-Ferreira AC, Torreglosa CR, da Silva JT, Coqueiro AY, Kuntz MGF, et al. Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: a systematic review and meta-analyses of randomized trials. Nutr Rev 2019. [ PubMed abstract] Szajewska H, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2015;42:793-801. [ PubMed abstract]
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